Publisher： John Wiley & Sons Inc
E-ISSN： 1365-2141|7-1048|2|376-378
ISSN： 0007-1048
Source： BRITISH JOURNAL OF HAEMATOLOGY, Vol.7-1048, Iss.2, 1996-08, pp. : 376-378
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Abstract
Mantle‐cell lymphoma (MCL) is a B‐cell tumour with a usually poor prognosis, characterized by the proliferation of small cleaved lymphocytes with a diffuse growth pattern. We report a polymerase chain reaction‐based analysis of minimal residual disease in a patient who achieved complete remission after allogeneic blood cell transplantation (BCT). Rearrangement of the immunoglobulin heavy‐chain genes was used to generate a lymphoma‐specific molecular marker. Lymphoma cells were not detectable in a bone marrow sample collected 12 months after BCT. Our findings suggest that allogeneic BCT may offer a curative approach to MCL.
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