

Publisher: John Wiley & Sons Inc
E-ISSN: 1439-0272|303-4569|9|1041-1046
ISSN: 0303-4569
Source: ANDROLOGIA (ELECTRONIC), Vol.303-4569, Iss.9, 2015-11, pp. : 1041-1046
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
SummaryNerve growth factor (NGF) was first found in the central nervous system and is now well known for its multiple pivotal roles in the nervous system and immune system. However, more and more evidences showed that NGF and its receptors TrkA and p75 were also found in the head and tail of spermatozoa, which indicate the possible effect of NGF on the sperm motility. Nevertheless, the exact role of NGF in the human sperm motility remains unclear until now. In this study, we investigated the effect of NGF on human sperm motility, and the results showed that NGF could promote human sperm motility in vitro by increasing the movement distance and the number of A grade spermatozoa. Further analysis demonstrated that NGF promoted the sperm motility in a dose‐dependent manner in vitro. These results may facilitate the further studies on human fertility and assisted reproduction techniques.
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