Publisher： John Wiley & Sons Inc
E-ISSN： 1521-3757|127|40|11966-11969
ISSN： 0044-8249
Source： ANGEWANDTE CHEMIE, Vol.127, Iss.40, 2015-09, pp. : 11966-11969
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Abstract
AbstractThe direct α‐vinylation of carbonyl compounds to form a quaternary stereocenter is a challenging transformation. It was discovered that δ‐oxocarboxylic acids can serve as masked vinyl compounds and be unveiled by palladium‐catalyzed decarbonylative dehydration. The carboxylic acids are readily available through enantioselective acrylate addition or asymmetric allylic alkylation. A variety of α‐vinyl quaternary carbonyl compounds are obtained in good yields, and an application in the first enantioselective total synthesis of (−)‐aspewentins A, B, and C is demonstrated.
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