Cover Picture: Direct Construction of the 9H‐Pyrrolo[1,2‐a]azepin‐9‐amine Skeleton via [4+3] Annulation of Alkyl 2‐Aroyl‐1‐chlorocyclo‐ propanecarboxylates (Adv. Synth. Catal. 13/2015)

Publisher： John Wiley & Sons Inc

E-ISSN： 1615-4169|357|13|2733-2733

ISSN： 1615-4150

Source： ADVANCED SYNTHESIS & CATALYSIS, Vol.357, Iss.13, 2015-09, pp. : 2733-2733

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

The front cover picture, provided by Yuefa Gong and co‐workers, illustrates a highly diastereoselective approach for direct synthesis of the important 9H‐pyrrolo[1,2‐a]azepin‐9‐amines. This transition metal‐free [4+3] annulation reaction between donor‐acceptor reagents derived from 1H‐pyrrole‐2‐carbaldehydes and alkyl 2‐aroyl‐1‐chlorocyclopropanecarboxylates proceeded quickly under mild basic conditions, affording azepin‐9‐amine derivatives in moderate to high yields with high diastereoselectivities. Details can be found in the communication on pages 2781–2787 (J. Hu, Y. Liu, Y. Gong, Adv. Synth. Catal. 2015 , 357, 2781–2787; DOI: 10.1002/adsc.201500376).