The obesity‐related FTO gene variant associates with the risk of recurrent miscarriage

E-ISSN： 1600-0412|94|7|722-726

ISSN： 0001-6349

Source： ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, Vol.94, Iss.7, 2015-07, pp. : 722-726

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Abstract

AbstractObjectiveTo investigate the association of the fat mass and obesity associated gene (FTO) rs9939609 single nucleotide polymorphism with recurrent miscarriage.DesignCandidate gene association study.SettingHuman Genetics Unit, Colombo, Sri Lanka.PopulationA total of 202 Sinhalese women with two or more first‐trimester miscarriages and no living children (cases) and 202 age‐ and ethnicity‐matched women with no history of miscarriage and having two or more living children (controls).MethodsPeripheral blood was collected from the participants and DNA was extracted. Genotyping was performed at the Australian genome Research Facility using the Sequenom MassARRAY system. Genotype and allele frequencies of cases were compared with controls using chi‐squared testing.Main outcome measuresThe prevalence of the single nucleotide polymorphism in cases and controls.ResultsThe mean age of the women in the recurrent miscarriage group was 31.9 ± 0.4 years and that of the control group was 32.3 ± 0.3 years. Of the women in the recurrent miscarriage group, 140 (69.3%) had experienced three or more first‐trimester miscarriages. The prevalence of the AA genotype [p = 0.0002, odds ratio (95% CI) = 3.8 (1.8–8.0)] and A allele [p = 0.002, odds ratio (95% CI) = 1.6 (1.2–2.2)] of the FTO rs9939609 single nucleotide polymorphism were increased in women in the recurrent miscarriage group compared with the control group.ConclusionThe obesity‐related FTO rs9939609 single nucleotide polymorphism associates with recurrent miscarriage. This finding warrants further investigation with controlling for important factors such as body mass index, diabetes and cardiovascular disease status. The single nucleotide polymorphism may be useful in predicting the risk of recurrent miscarriage.