Solid‐Phase Friedländer Synthesis Using an Alkoxyamine Linker

Publisher: John Wiley & Sons Inc

E-ISSN: 1099-0690|2015|22|4990-4995

ISSN: 1434-193x

Source: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol.2015, Iss.22, 2015-08, pp. : 4990-4995

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Abstract

AbstractA quinoline library was prepared by combinatorial synthesis using an alkoxyamine linker. Substrates were loaded onto a solid support containing an oxime linkage. After selected reactions on the solid support, the products were cleaved by a Friedländer‐type reaction with ketones under acidic conditions to afford the corresponding quinolines. The recyclability of the solid support was also investigated.