Multimodal Nanoparticle for Primary Tumor Delineation and Lymphatic Metastasis Mapping in a Head‐and‐Neck Cancer Rabbit Model

Publisher: John Wiley & Sons Inc

E-ISSN: 2192-2659|4|14|2164-2169

ISSN: 2192-2640

Source: ADVANCED HEALTHCARE MATERIALS (ELECTRONIC), Vol.4, Iss.14, 2015-10, pp. : 2164-2169

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Abstract

64Cu‐porphysome nanoparticles enable superior delineation of neoplastic tissues, metastatic lymph nodes, and vascular drainage on head and neck cancer orthotopic rabbit model using positron emission tomography imaging. Additionally, the nanoparticles exhibit selective fluorescence activation in tumor and metastatic lymph nodes, which permits intraoperative real‐time visualization of disease tissues to precisely define surgical margins and prevents collateral damage during surgeries.

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