Publisher： John Wiley & Sons Inc
E-ISSN： 1521-3773|54|19|5628-5631
ISSN： 1433-7851
Source： ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol.54, Iss.19, 2015-05, pp. : 5628-5631
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Abstract
AbstractThe activation of CD8+ T‐cells requires the uptake of exogenous polypeptide antigens and proteolytic processing of these antigens to octamer or nonamer peptides, which are loaded on MHC‐I complexes and presented to the T‐cell. By using an azide as a bioorthogonal protecting group rather than as a ligation handle, masked antigens were generated—antigens that are not recognized by their cognate T‐cell unless they are deprotected on the cell using a Staudinger reduction.
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