Gold‐Catalyzed Cascade Cyclization of 2‐Alkynyl‐N‐Propargylanilines by Rearrangement of a Propargyl Group

Publisher: John Wiley & Sons Inc

E-ISSN: 1521-3757|127|27|7973-7977

ISSN: 0044-8249

Source: ANGEWANDTE CHEMIE, Vol.127, Iss.27, 2015-06, pp. : 7973-7977

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Abstract

AbstractGold catalysis enables direct construction of tetracyclic fused indolines through the migration of a propargyl substituent from an aniline nitrogen atom to the C3‐position of an indole from 2‐alkynyl‐N‐propargylanilines. This reaction provides rapid access to fused three‐dimensional indolines in a single operation with the formation of four bonds and three rings.