Publisher： John Wiley & Sons Inc
E-ISSN： 1521-3757|127|22|6667-6670
ISSN： 0044-8249
Source： ANGEWANDTE CHEMIE, Vol.127, Iss.22, 2015-05, pp. : 6667-6670
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Abstract
AbstractA nanoparticle design featuring pH‐responsive alkoxyphenyl acylsulfonamide ligands is reported herein. As a result of ligand structure, this nanoparticle is neutral at pH 7.4, becoming positively charged at tumor pH (<6.5). The particle uptake and cytotoxicity increase over this pH range. This pH‐controlled uptake and toxicity makes this particle a promising tool for tumor selective therapy.
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