Publisher： John Wiley & Sons Inc
E-ISSN： 1521-3765|21|29|10450-10456
ISSN： 0947-6539
Source： CHEMISTRY - A EUROPEAN JOURNAL, Vol.21, Iss.29, 2015-07, pp. : 10450-10456
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
AbstractThe use of click chemistry reactions for the functionalization of nanoparticles is particularly useful to modify the surface in a well‐defined manner and to enhance the targeting properties, thus facilitating clinical translation. Here it is demonstrated that olefin metathesis can be used for the chemoselective functionalization of iron oxide nanoparticles with three different examples. This approach enables, in one step, the synthesis and functionalization of different water‐stable magnetite‐based particles from oleic acid‐coated counterparts. The surface of the nanoparticles was completely characterized showing how the metathesis approach introduces a large number of hydrophilic molecules on their coating layer. As an example of the possible applications of these new nanocomposites, a focus was taken on atherosclerosis plaques. It is also demonstrated how the in vitro properties of one of the probes, particularly its Ca2+‐binding properties, mediate their final in vivo use; that is, the selective accumulation in atherosclerotic plaques. This opens promising new applications to detect possible microcalcifications associated with plaque vulnerability. The accumulation of the new imaging tracers is demonstrated by in vivo magnetic resonance imaging of carotids and aorta in the ApoE−/− mouse model and the results were confirmed by histology.
Related content
Access to resources
Recommend
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION (ELECTRONIC), Vol. 32, Iss. 2, 2015-02 ,pp. :
Surface‐Confined Dynamic Covalent System Driven by Olefin Metathesis
ANGEWANDTE CHEMIE, Vol. 130, Iss. 7, 2018-02 ,pp. :
Surface‐Confined Dynamic Covalent System Driven by Olefin Metathesis
ANGEWANDTE CHEMIE INTERNATIONAL EDITION, Vol. 57, Iss. 7, 2018-02 ,pp. :