Publisher： John Wiley & Sons Inc
E-ISSN： 1615-4169|357|6|1299-1304
ISSN： 1615-4150
Source： ADVANCED SYNTHESIS & CATALYSIS, Vol.357, Iss.6, 2015-04, pp. : 1299-1304
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
AbstractThe direct asymmetric vinylogous Michael addition of 3,5‐dialkyl‐substituted 4‐nitroisoxazoles with α,β‐unsaturated aldehydes catalyzed by a diphenylprolinol TBS ether organocatalyst is described, giving products with moderate to good yields and up to excellent enantioselectivities (96% ee). This approach provides an easy access to highly functionalized chiral isoxazole derivatives.
Related content
Access to resources
Recommend
