Publisher： John Wiley & Sons Inc
E-ISSN： 1751-553x|37|S1|92-98
ISSN： 1751-5521
Source： International Journal Of Laboratory Hematology, Vol.37, Iss.S1, 2015-05, pp. : 92-98
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Abstract
SummaryHepatic hormone hepcidin is a principal regulator of iron homeostasis and a pathogenic factor in common iron disorders. Hepcidin deficiency causes iron overload in hereditary hemochromatosis and iron‐loading anemias, whereas hepcidin excess causes or contributes to the development of iron‐restricted anemia in inflammatory diseases, infections, some cancers, and chronic kidney disease. Because of this, hepcidin may become a useful tool for diagnosis and management of iron disorders. Furthermore, a number of strategies that target hepcidin, its receptor, and its regulators are under development as novel therapeutic approaches for diseases associated with iron dysregulation.
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