evaluation of iron in skin employing

Author： Estevam Marcelo Appoloni Carlos Roberto Malvezi Aparecida Donizette Tatakihara Vera Lúcia Hideko Panis Carolina Cecchini Rubens Rizzo Luiz Vicente Pinge-Filho Phileno

Publisher： Blackwell Publishing

ISSN： 0928-8244

Source： FEMS Immunology & Medical Microbiology, Vol.64, Iss.3, 2012-04, pp. : 334-342

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

AbstractTrypanosoma cruzi, the causative agent of Chagas’ disease (CD), is a substantial public health concern in Latin America. Laboratory mice inoculated with T. cruzi have served as important animal models of acute CD. Host hypoferremic responses occur during T. cruzi infection; therefore, it has been hypothesized that T. cruzi requires iron for optimal growth in host cells and, unlike extracellular pathogens, may benefit from host hypoferremic responses. Recent technological improvements of X-ray fluorescence are useful for diagnostics or monitoring in biomedical applications. The goal of our study was to determine whether the iron availabilities in Swiss and C57BL/6 mice differ during the acute phase of T. cruzi infection and whether the availability correlates with oxidative stress in the susceptible and resistant phenotypes identified in these mice. Our results showed that the decrease in iron levels in the skin of resistant infected mice correlated with the increase in oxidative stress associated with anemia and the reduction in parasite burden.