Immunogenicity and efficacy of an anthrax/plague

Author： Albrecht Mark T.   Eyles Jim E.   Baillie Les W.   Keane-Myers Andrea M.  

Publisher： Blackwell Publishing

ISSN： 0928-8244

Source： FEMS Immunology & Medical Microbiology, Vol.65, Iss.3, 2012-08, pp. : 505-509

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Abstract

AbstractThe efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor (LFn) fused to either Yersinia pestis V antigen (V) or Y . pestis F1 was evaluated. A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y. pestis.

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