Function of CBFβ/Bro proteins

ISSN： 1084-9521

Source： Seminars in Cell and Developmental Biology, Vol.11, Iss.5, 2000-10, pp. : 361-368

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Mammalian core binding factor β(CBF β) and Drosophila Brother (Bro) and Big-brother (Bgb) proteins are transcription factors that dimerize with mammalian Runx and Drosophila Runt and Lozenge proteins and augment their DNA binding affinity and transcriptional potency. CBF β is essential for development and sustenance of definitive hematopoiesis during mouse embryogenesis. Bro and Bgb are required for Runt/Lozenge functions in Drosophila development. CBF β contributes to leukemogenesis since the CBFB gene is specifically and consistently mutated by a chromosome 16 inversion found in patients with acute myeloid leukemia subtype M4Eo. The ubiquitous expression pattern of the CBFB gene suggests that it may play important roles in many other organ systems.

Related content

Intercellular Ca²⁺signalling: the artery wall

By Dora K.A.

Seminars in Cell and Developmental Biology, Vol. 12, Iss. 1, 2001-02 ,pp. : 27-35 (9)

Academic Press

Access to resources Recommend Favorite

Runt and Lozenge function in Drosophila development

By Canon J. Banerjee U.

Seminars in Cell and Developmental Biology, Vol. 11, Iss. 5, 2000-10 ,pp. : 327-336 (10)

Academic Press

Access to resources Recommend Favorite

Genetic dissection of proteoglycan function in Drosophila and C. elegans

By Selleck S.B.

Seminars in Cell and Developmental Biology, Vol. 12, Iss. 2, 2001-04 ,pp. : 127-134 (8)

Academic Press

Access to resources Recommend Favorite

Vigna vexillata (L.) A. Rich. Cultivated as a Root Crop in Bali and Timor

By Karuniawan A. Iswandi A. Kale P. Heinzemann J. Grüneberg W.

Genetic Resources and Crop Evolution, Vol. 53, Iss. 1, 2006-02 ,pp. : 213-217 (5)

Springer Publishing Company

Access to resources Recommend Favorite

Ca²⁺signalling during fertilization of echinoderm eggs

By Jaffe L.A. Giusti A.F. Carroll D.J. Foltz K.R.

Seminars in Cell and Developmental Biology, Vol. 12, Iss. 1, 2001-02 ,pp. : 45-51 (7)

Academic Press

Access to resources Recommend Favorite