Author: Bonetti F. Pea M. Martignoni G. Doglioni C. Zamboni G. Capelli P. Rimondi P. Andrion A.
Publisher: Ashgate Publishing Ltd
ISSN: 0031-3025
Source: Pathology, Vol.26, Iss.3, 1994-07, pp. : 230-236
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
We report a comparative study of 3 clear cell tumors of the lung (CCTL) and 3 angiomyolipomas (AML) of the kidney. Morphological analysis shows that the cells of CCTL are identical to the perivascular epithelioid component of AML. Phenotypically they both consistently expressed melanoma-associated antigens recognized by Moabs HMB45 and HMSA-1, while they were negative for HMSA-5. A minority of cells also expressed S-100 protein, vimentin and actin. In addition, one case of CCTL showed mature adipose tissue entrapped in the proliferation, thus suggesting an intermediate form between CCTL and AML. Based on morphological and phenotypical similarities, it is suggested that CCTL and AML belong to the same family of lesions, characterized by the presence of a peculiar muscle cell, expressing different melanoma-associated antigens.
Related content
Clear cell carcinoma of the urinary bladder
By Lum Dennis
Pathology, Vol. 38, Iss. 4, 2006-08 ,pp. :
By Roeder Falk Friedrich Jochen Timke Carmen Kappes Jutta Huber Peter Krempien Robert Debus Juergen Bischof Marc
Strahlentherapie und Onkologie, Vol. 186, Iss. 3, 2010-03 ,pp. :