Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer

Author： van Leeuwen* F.   Nusse R.  

Publisher： Academic Press

ISSN： 1044-579X

Source： Seminars in Cancer Biology, Vol.6, Iss.3, 1995-06, pp. : 127-133

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

In this short review, we will give an overview of the various genes that can be activated by insertion of proviral DNA of the mouse mammary tumor virus during the formation of mammary cancer. These genes fall within three families:Wntgenes,FGFgenes andNotch-related genes. We will summarize our current understanding of the roles of these genes in tumorigenesis and in normal development, and the mechanisms of action of their gene products. Finally, we will give some examples of cooperation between these genes in various biological settings.

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