Optimization of Diarylthiazole B‐Raf Inhibitors: Identification of a Compound Endowed with High Oral Antitumor Activity, Mitigated hERG Inhibition, and Low Paradoxical Effect

Publisher： John Wiley & Sons Inc

E-ISSN： 1860-7187|10|2|276-295

ISSN： 1860-7179

Source： CHEMMEDCHEM, Vol.10, Iss.2, 2015-02, pp. : 276-295

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Related content

Development of Safe Drugs: The hERG Challenge

By  

MEDICINAL RESEARCH REVIEWS, Vol. 38, Iss. 2, 2018-03 ,pp. : 525-555

John Wiley & Sons Inc

Access to resources Recommend Favorite

Stereoselective Block of hERG Channel by Bupivacaine Scrutinized at Molecular Level

By Grilo Liliana Sintra  

CHIMIA International Journal for Chemistry, Vol. 64, Iss. 3, 2010-03 ,pp. : 165-169

Swiss Chemical Society

Access to resources Recommend Favorite

Assessment of temperature‐induced hERG channel blockade variation by drugs

By  

JOURNAL OF APPLIED TOXICOLOGY, Vol. 35, Iss. 7, 2015-07 ,pp. : 799-805

John Wiley & Sons Inc

Access to resources Recommend Favorite

Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models

By  

JOURNAL OF APPLIED TOXICOLOGY, Vol. 38, Iss. 4, 2018-04 ,pp. : 450-458

John Wiley & Sons Inc

Access to resources Recommend Favorite

Optimization of compound layer thickness for wear resistance of nitrocarburized H11 steels

By Krishnaraj N.   Iyer K.J.L.   Sundaresan S.   Bala Srinivasan P.  

Wear, Vol. 215, Iss. 1, 1998-03 ,pp. : 123-130

Elsevier

Access to resources Recommend Favorite