Preclinical pharmacokinetic/pharmacodynamic/efficacy relationships for alisertib, an investigational small-molecule inhibitor of Aurora A kinase

Author： Palani Santhosh   Patel Mayankbhai   Huck Jessica   Zhang Mengkun   Balani Suresh   Yang Johnny   Chen Susan   Mettetal Jerome   Manfredi Mark   Shyu Wen   Ecsedy Jeffrey   Chakravarty Arijit  

Publisher： Springer Publishing Company

ISSN： 0344-5704

Source： Cancer Chemotherapy and Pharmacology, Vol.72, Iss.6, 2013-12, pp. : 1255-1264

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Related content

Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia

By                    

International Journal of Oncology, Vol. 41, Iss. 4, 2012-01 ,pp. : 1475-1485

Spandidos Publications

Access to resources Recommend Favorite

The inhibition of tyrosine kinase receptor signalling in leiomyosarcoma cells using the small molecule kinase inhibitor PTK787/ZK222584 (Vatalanib®)

By  

International Journal of Oncology, Vol. 45, Iss. 6, 2014-01 ,pp. : 2267-2277

Spandidos Publications

Access to resources Recommend Favorite

Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy

By                    

International Journal of Oncology, Vol. 45, Iss. 3, 2014-01 ,pp. : 1099-1108

Spandidos Publications

Access to resources Recommend Favorite

A Small-molecule Inhibitor, 5'-O-Tritylthymidine, Targets FAK and Mdm-2 Interaction, and Blocks Breast and Colon Tumorigenesis in vivo

By  

Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Cancer Agents), Vol. 13, Iss. 4, 2013-05 ,pp. : 532-545

Bentham Science Publishers

Access to resources Recommend Favorite

In vivo analysis of insulin-like growth factor type 1 receptor humanized monoclonal antibody MK-0646 and small molecule kinase inhibitor OSI-906 in colorectal cancer

By            

Oncology Reports, Vol. 31, Iss. 1, 2014-01 ,pp. : 87-94

Spandidos Publications

Access to resources Recommend Favorite