MicroRNA‐34c‐5p is related to recurrence in laryngeal squamous cell carcinoma

Publisher: John Wiley & Sons Inc

E-ISSN: 1531-4995|125|9|E306-E312

ISSN: 0023-852x

Source: THE LARYNGOSCOPE, Vol.125, Iss.9, 2015-09, pp. : E306-E312

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Abstract

Objectives/HypothesisAltered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). We investigated the association of LSCC‐related miR‐34c‐5p with disease‐free survival and overall survival.Study DesignRetrospective cohort study.MethodsExpression levels of miR‐34c‐5p were detected in 90 LSCC formalin‐fixed paraffin‐embedded tissues by reverse‐transcription quantitative polymerase chain reaction. Overall survival and disease‐free survival were evaluated using the Kaplan‐Meier method, and multivariate analysis was performed using Cox proportional hazard analysis.ResultsA downregulation of miR‐34c‐5p expression significantly correlated with worse disease‐free and overall survival. In the multivariate analysis, low miR‐34c‐5p expression was associated with an increased risk of recurrence.ConclusionsA downregulation of miR‐34c‐5p in LSCC is independently associated with unfavorable disease‐free survival, suggesting that miR‐34c‐5p might be a promising marker for evaluating the risk of recurrences.Level of EvidenceNA Laryngoscope, 125:E306–E312, 2015

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