Desulfitative palladium‐catalyzed direct C‐3 arylation of indolizines with arylsulfonyl chlorides

Publisher: John Wiley & Sons Inc

E-ISSN: 1099-0739|29|8|524-527

ISSN: 0268-2605

Source: APPLIED ORGANOMETALLIC CHEMISTRY (ELECTRONIC), Vol.29, Iss.8, 2015-08, pp. : 524-527

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

An efficient Pd‐catalyzed desulfitative approach to C‐3 arylation of indolizine derivatives has been developed, and the protocol uses readily available arylsulfonyl chlorides as the arylation reagent under nitrogen. This transformation was performed in a mixed solvent of 1‐methyl‐2‐pyrrolidone and dimethoxyethane using simple triphenylphosphine as a ligand, which provides a new method for the C‐3 arylation of indolizines. Copyright © 2015 John Wiley & Sons, Ltd.