Publisher： John Wiley & Sons Inc
E-ISSN： 1522-2586|41|6|1608-1614
ISSN： 1053-1807
Source： JOURNAL OF MAGNETIC RESONANCE IMAGING, Vol.41, Iss.6, 2015-06, pp. : 1608-1614
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Abstract
PurposeTo investigate the feasibility of dynamic, contrast‐enhanced, magnetic resonance imaging (DCE‐MRI) for perfusion quantification of gastric cancers, and to correlate the DCE‐MRI parameters with the pathological prognostic factors.Materials and MethodsThis prospective study was approved by our Institutional Review Board. Twenty‐seven patients with gastric cancers underwent DCE‐MRI using a free‐breathing, radial, gradient‐echo (GRE) sequence with k‐space weighted image contrast (KWIC) reconstruction on a 3T scanner. The DCE‐MRI parameters (volume transfer coefficient [Ktrans], reverse reflux rate constant [Kep], extracellular extravascular volume fraction [Ve], and initial area under the gadolinium concentration curve during the first 60 seconds [iAUC]) of gastric cancer and normal wall were measured and compared with each other using the Wilcoxon signed rank test. The relationship between the DCE‐MRI parameters of gastric cancer and the pathological prognostic factors were evaluated using the Mann–Whitney test or the Spearman rank correlation test.ResultsDCE‐MRIs were of diagnostic quality in 22 patients (81.5%). Ve and iAUC were significantly higher in gastric cancer than in normal gastric wall (P < 0.05). Ve showed significant positive correlation with T‐staging of gastric cancers (P < 0.05). Ktrans was significantly correlated with the grades of epidermal growth‐factor receptor expression (P < 0.05).ConclusionDCE‐MRI using a radial GRE with KWIC reconstruction is feasible for quantification of the perfusion dynamics of gastric cancers, and the DCE‐MRI parameters of gastric cancers may provide prognostic information. J. Magn. Reson. Imaging 2015;41:1608–1614. © 2014 Wiley Periodicals, Inc.
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