Structure of GTP‐specific succinyl‐CoA synthetase in complex with CoA

Publisher: John Wiley & Sons Inc

E-ISSN: 2053-230x|71|8|1067-1071

ISSN: 2053-230x

Source: ACTA CRYSTALLOGRAPHICA SECTION F (ELECTRONIC), Vol.71, Iss.8, 2015-08, pp. : 1067-1071

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Abstract

Pig GTP‐specific succinyl‐CoA synthetase is an αβ‐heterodimer. The crystal structure of the complex with the substrate CoA was determined at 2.1 Å resolution. The structure shows CoA bound to the amino‐terminal domain of the α‐subunit, with the free thiol extending from the adenine portion into the site where the catalytic histidine residue resides.