Author: Matsuo K Oka M Murase K Soda H Isomoto H Takeshima F Mizuta Y Murata I Kohno S
Publisher: Field House Publishing
ISSN: 0300-0605
Source: The Journal of International Medical Research, Vol.31, Iss.2, 2003-03, pp. : 69-75
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Interleukin 6 (IL-6) is a pleiotropic cytokine with many physiological functions. The present study was designed to determine the expression of IL-6 and its receptor (IL-6R) in human gastric and colorectal cancers. Nine gastric- and nine colorectal cancer cell lines were analysed. The IL-6 gene was expressed in two gastric cancer cell lines and one colorectal cancer cell line; however, most of the cancer cell lines studied expressed the IL-6R gene. The level of IL-6 secretion in the gastric cancer cell lines correlated with the level of soluble IL-6R secretion, and was significantly higher (< ∼100 pg/ml) than the level of IL-6 secretion in the colorectal cancer cell lines (< ∼50 pg/ml). These results suggest that IL-6 may act in a paracrine fashion rather than an autocrine fashion in these cell lines.
Related content
By Evans N.M. Bose S. Benedetti G. Zwart R. Pearson K.H. McPhie G.I. Craig P.J. Benton J.P. Volsen S.G. Sher E. Broad L.M.
European Journal of Pharmacology, Vol. 466, Iss. 1, 2003-04 ,pp. :
Mannose 6-Phosphate Receptor Targeting and its Applications in Human Diseases
Current Medicinal Chemistry, Vol. 14, Iss. 28, 2007-12 ,pp. :
By Narang Ajit Sabek Omaima Gaber Ahmed Mahato Ram
Pharmaceutical Research, Vol. 23, Iss. 9, 2006-09 ,pp. :