The structure of the hypothetical protein smu.1377c from Streptococcus mutans suggests a role in tRNA modification

Publisher: John Wiley & Sons Inc

E-ISSN: 1744-3091|66|7|771-775

ISSN: 1744-3091

Source: Acta Crystallographica Section F, Vol.66, Iss.7, 2010-06, pp. : 771-775

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Abstract

Members of the Sua5_YciO_YrdC protein family are found in both eukaryotes and prokaryotes and possess a conserved α/β twisted open‐sheet fold. The Escherichia coli protein YrdC has been shown to be involved in modification of tRNA. The crystal structure of smu.1377c, a hypothetical protein from Streptococcus mutans, has been determined to 2.25 Å resolution. From structure analysis and comparison, it is shown that smu.1377c is a member of the Sua5_YciO_YrdC family and that it may play the same role as E. coli YrdC.