Publisher: Karger
E-ISSN: 1424-859x|135|2|84-92
ISSN: 1424-8581
Source: Cytogenetic and Genome Research, Vol.135, Iss.2, 2011-10, pp. : 84-92
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Abstract
BRCA1 is a major gatekeeper of genomic stability. Acting in multiple central processes like double-strand break repair, centrosome replication, and checkpoint control, BRCA1 participates in maintaining genomic integrity and protects the cell against genomic instability. Chromosomal instability (CIN) as part of genomic instability is an inherent characteristic of most solid tumors and is also involved in breast cancer development. In this study, we determined the extent of CIN in 32 breast cancer tumors of women with a
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