Biocompatibility of Cellulose Sponge with Bone

Publisher: Karger

E-ISSN: 1421-9921|30|6|426-432

ISSN: 0014-312x

Source: European Surgical Research, Vol.30, Iss.6, 1998-12, pp. : 426-432

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Abstract

The purpose of this study was to investigate the biocompatibility of viscose cellulose sponge (VCS) with bone. Twenty-five Sprague-Dawley rats were used for the study. After curettage of the bone marrow from both femoral cavities, VCS (15 × 1 × 1 mm) was implanted into one femur, leaving the contralateral side empty as a control. The rats were killed 1–6 weeks after curettage, and bone formation inside the sponge was assessed by light-microscopic examination and histomorphometric assessment. Whereas normal bone formation in rat femoral cavity took place in 2 weeks after curettage, 4 weeks were needed for bone formation in the cellulose sponge. VCS is a compatible matrix for osseous tissue ingrowth and it may be useful as a scaffold for bone tissue engineering in experiments and possibly also in clinical practice.