Genome-Wide Scan for Quantitative ACE Activity in Taiwan Young-Onset Hypertension Study

Publisher： Karger

E-ISSN： 1423-0062|65|2|85-90

ISSN： 0001-5652

Source： Human Heredity, Vol.65, Iss.2, 2007-09, pp. : 85-90

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Abstract

Objectives: Angiotensin converting enzyme (ACE) plays major roles in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACEvariants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58). Methods: With 1,271 individuals from 373 young-onset (age ≤40) hypertension pedigrees, 479 deCODE microsatellite markers were genotyped. Results: We identified a previously unknown loci on chromosomes 9 at 149.4 cM (LOD = 3.00) in addition to a strong linkage peak near the ACE structural locus on chromosome 17 at 89.6 cM (LOD = 4.60). Conclusions: These results not only indicate that the ACE gene or nearby loci on 17q was among the strongest QTL influencing ACE activity, but also reveal a potential ACE QTL in human genome, pointing to the complexity of ACE regulation.