Antigen-Induced Airway Migration of a T Helper 2 Clone

Publisher： Karger

E-ISSN： 1423-0097|124|1-3|287-289

ISSN： 1018-2438

Source： International Archives of Allergy and Immunology, Vol.124, Iss.1-3, 2012-01, pp. : 287-289

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Abstract

Background: The crucial role of T helper (Th) 2 cells in allergic eosinophilic inflammation has been established. Methods: To determine the dynamics of Th2 cells in airway eosinophilic inflammation, ovalbumin-reactive murine Th2 clones were infused into unprimed mice. Results: The infused T cells were activated and migrated into the bronchial submucosa upon provocation with the relevant inhaled antigen. The T cell migration was followed by massive eosinophilic infiltration, edema, swelling of epithelial cells in the lung and a significant increase in bronchial responsiveness to acetylcholine. Conclusion: Clonal Th2 cells have the potential to accumulate and induce eosinophilic inflammation in the lung upon antigenic stimulation.

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