Importance of Toll-Like Receptor 9 in Host Defense against M1T1 Group A Streptococcus Infections

Publisher: Karger

E-ISSN: 1662-8128|4|2|213-218

ISSN: 1662-811x

Source: Journal of Innate Immunity, Vol.4, Iss.2, 2011-08, pp. : 213-218

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Abstract

Timely recognition and elimination of invasive group A Streptococcus (GAS) by innate immunity is crucial to control infection. The intracellular pattern recognition receptor Toll-like receptor 9 (TLR9) promotes macrophage hypoxia-inducible factor-1α levels, oxidative burst and nitric oxide production in response to GAS. TLR9 contributes to GAS clearance in vivo in both localized cutaneous and systemic infection models.