Publisher： Karger
E-ISSN： 1423-0208|23|3|135-143
ISSN： 0251-5350
Source： Neuroepidemiology, Vol.23, Iss.3, 2004-04, pp. : 135-143
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
In a cohort study, 1,301 subjects free of dementia at baseline in the Kungsholmen Project were followed up to 6 years. We studied the association between use of aspirin and non-steroidal anti-inflammatory drugs (NSAIDs), incidence of Alzheimer’s disease (AD) and overall dementia, and the influence of the apolipoprotein E Ε4 allele. In stratified analyses, a relative risk (RR) of 1.80 (95% CI 1.14–2.83) for AD was seen, in the apoE Ε4-negative group using aspirin. This implicates a possible different mechanism of developing AD in this group. We also found a possible protective effect of NSAIDs against AD, since no one who used NSAIDs for around 3 years had developed AD 3 years later. One user developed vascular dementia, and a low point value of risk was seen, however, not significant (RR 0.23; 95% CI 0.03–1.68). This could be due to the small samples in our study, or to comorbidity contributing to the development of dementia in this elderly population.
Related content
Access to resources
Recommend
Apolipoprotein E υ4 Allele Frequency in Vascular Dementia
Dementia and Geriatric Cognitive Disorders, Vol. 22, Iss. 1, 2006-06 ,pp. :
Apolipoprotein E ε4 Allele Is Associated with Vascular Dementia
Dementia and Geriatric Cognitive Disorders, Vol. 22, Iss. 4, 2006-10 ,pp. :