Publisher： Karger
E-ISSN： 1660-5535|12|1-2|85-89
ISSN： 1660-5527
Source： Skin Pharmacology and Physiology, Vol.12, Iss.1-2, 1999-05, pp. : 85-89
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Abstract
The existence of a stratum corneum reservoir for topically applied substances is well known. Data concerning the stratum corneum retention time are important for the elaboration of optimal topical treatment. We used the re-occlusion technique followed by skin colour measurements (Chromametry) for the evaluation of the stratum corneum retention time of halcinonide. We found a significant reservoir for halcinonide up to 5 days after the initial application. The retention was found to be corticosteroid concentration and formulation dependent.
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