Publisher： Karger
E-ISSN： 1660-3818|33|1|38-44
ISSN： 1660-3796
Source： Transfusion Medicine and Hemotherapy, Vol.33, Iss.1, 2006-01, pp. : 38-44
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Abstract
Glycosylation is the most common and most diverseposttranslational modification of proteins. During tumorigenesisaltered glycosylation patterns are a hallmark.In addition, changes in glycosylation are importantin autoimmune diseases, such as rheumatoid arthritis.MHC class I- as well as MHC class II-presented glycopeptideshave been described, and both CD8+ and CD4+ Tcells are able to recognize glycopeptides in a classicalMHC-restricted way. Different glycosylation patterns mayinfluence T cell responses during disease, creatingneoepitopes or blocking existing T cell responses to unmodifiedpeptides by changing epitopes or abolishingbinding to MHC molecules. In the present review, we discussthe current knowledge of glycosylated MHC class Iand II peptides - which peptides have been described,and what is their impact on cellular immunity.
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