Recent Advances in Ligand and Structure Based Screening of Potent Quorum Sensing Inhibitors Against Antibiotic Resistance Induced Bacterial Virulence

Publisher： Bentham Science Publishers

E-ISSN： 2212-4012|10|2|195-216

ISSN： 1872-2083

Source： Recent Patents on Biotechnology, Vol.10, Iss.2, 2016-10, pp. : 195-216

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Abstract

Background: Antibiotic resistance is a growing threat in the treatment ofbacterial diseases. Bacterial invasion and its virulence can cause damage to the hostcells via quorum sensing mechanism which is responsible for the intercellular communicationamong bacteria that regulates expression of many genes. Quorum sensing(QS) differentially expresses specific sets of genes which may produce resistance.Researchers have been devoted to develop more potent compounds againstbacterial resistant quorum sensing inhibitors.lt;/pgt

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