Association of Metabolic Syndrome with Microalbuminuria in Non-Hypertensive Type 2 Diabetic Patients

Publisher: Karger

E-ISSN: 1660-2110|106|3|c98-c103

ISSN: 1660-2110

Source: Nephron Clin Pract, Vol.106, Iss.3, 2007-05, pp. : c98-c103

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Abstract

Background: Several studies have shown that metabolic syndrome contributed to the development of incident chronic kidney disease in the general population. We evaluated the cross-sectional association between metabolic syndrome and microalbuminuria in patients with type 2 diabetes. We excluded patients with hypertension to distinguish the effects of metabolic syndrome from those of hypertension. Methods: A total of 642 non-hypertensive patients with type 2 diabetes were recruited. Metabolic syndrome was assessed according to the NCEP Guidelines and Asian-Pacific criteria for abdominal obesity. Results: Among all patients, 37.2% were diagnosed as having metabolic syndrome, and these patients had a higher prevalence of microalbuminuria than those without metabolic syndrome (19.7 vs. 13.6%, p = 0.044). There was a graded association between metabolic score and the prevalence of microalbuminuria (p = 0.006 for trend). After adjustment for sex, age, smoking status, C-reactive protein, and HbA1c, patients with metabolic syndrome had increased odds of 1.58 (95% CI 1.01–2.47) for microalbuminuria. An increment in metabolic score was found to increase the risk of microalbuminuria by 1.34-fold (95% CI 1.07–1.66, p = 0.008). Conclusion: This study demonstrated that metabolic syndrome was associated with an increased risk of microalbuminuria in non-hypertensive patients with type 2 diabetes.

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