Central Venous Oxygen Saturation: A Potential New Marker for Circulatory Stress in Haemodialysis Patients?

Publisher： Karger

E-ISSN： 1660-2110|128|1-2|57-60

ISSN： 1660-2110

Source： Nephron Clin Pract, Vol.128, Iss.1-2, 2014-10, pp. : 57-60

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Abstract

Background/Aims: Haemodialysis causes recurrent haemodynamic stress with subsequent ischaemic end-organ dysfunction. As dialysis prescriptions/schedules can be modified to lessen this circulatory stress, an easily applicable test to allow targeted interventions in vulnerable patients is urgently required. Methods: Intra-dialytic central venous oxygen saturation (ScvO₂) and clinical markers (including ultrafiltration, blood pressure) were measured in 18 prevalent haemodialysis patients. Results: Pre-dialysis ScvO₂ was 63.5 ± 13% and fell significantly to 56.4 ± 8% at end dialysis (p = 0.046). Ultrafiltration volume, a key driver of dialysis-induced myocardial ischaemia, inversely correlated to ScvO₂ (r = -0.680, p = 0.015). Conclusions: This initial study demonstrates ScvO₂ sampling is practical, with a potential clinical utility as an indicator of circulatory stress during dialysis.