Curcumin Intra-oral Controlled Release Films for Oral Candidiasis: A Comparative Study with Fluconazole, Elucidation of Release Mechanism

Publisher： Bentham Science Publishers

E-ISSN： 2212-3903|13|1|43-55

ISSN： 1574-8855

Source： Current Drug Therapy, Vol.13, Iss.1, 2018-04, pp. : 43-55

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Abstract

Objective: This research work aimed to develop bucco-adhesive patches,which release curcumin in the oral cavity for an extended duration thereby assisting in thecure of oral thrush (candidiasis). Fluconazole containing patches were also developed inorder to compare the effectiveness of curcumin patches against Candida albicans.

Method: After suitable preformulation studies, five formulations of curcumin were preparedusing Eudragit S100 and polyvinyl alcohol (PVA) in varying ratios. Three batchesof fluconazole formulations were prepared without PVA. Patches were evaluated for theirphysical properties and chemical integrity. Newer techniques were developed to determinetheir bioadhesion and tensile strength. Sterile formulations of P3 and F2 were preparedand compared for the antifungal activity against C. albicans, by zone of inhibitionmethod.

Results: All formulations exhibited satisfactory tensile strength ranging from 0.282 to0.411 Kg/m2 with good folding endurance. Formulations containing higher amount ofPVP exhibited better bioadhesive strength. P3 formulation containing curcumin and F2formulation of fluconazole were found to sustain the drug release upto 5 hours. An increasingamount of PVA retarded the drug release. In antifungal studies, the zone of inhibitionfor P3 patches was 19mm, and for F2 patches, it was 13mm, indicating a better invitro antifungal activity for curcumin against fluconazole. SEM analysis of P3 formulationsrevealed continuous, non-porous but non homogenous structure of the polymer film.

Conclusion: The effectiveness of curcumin buccal patches in superior to fluconazole patcheswas well demonstrated. Mathematical modelling of drug release data indicated a first orderanomalous transport causing the drug release. Kinetic modelling with zero, first order,Higuchi and Korsmeyer- peppas are explained in this article.