Publisher： Bentham Science Publishers
E-ISSN： 2212-3911|13|1|44-50
ISSN： 1574-8863
Source： Current Drug Safety, Vol.13, Iss.1, 2018-03, pp. : 44-50
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Abstract
Objective: Evaluation of the cause of complaints and laboratory abnormalities and the involvement ofartichoke infusion. Results: The prominence of the inflammatory parameters was ruled out because of exhaustiveautoimmune, infectious or para-neoplastic syndrome (blood cultures, serology, diagnostic imaging,bone marrow and bone biopsy, muscle biopsy and nerve, abdominal angiography) were carried outshowing normal results. The evaluation pointed out that the concomitant intake of artichoke infusionmay have been involved in the framework developed, since the drugs which were being administeredto/by the patient have a metabolism mainly mediated by CYP450 3A4 and 2C9 that could becompromised when these isoenzymes are inhibited by phenolic and flavonoid compounds from plants.Colchicine was one of the last drugs took that have as side effects most of the symptoms felt by patientincluding diarrhea and anemia. Conclusion: The spontaneous and complete recovery of the patient and the negativity of researchlooking for other causes, conduce to a strong possibility of the interaction between artichoke and thedrugs in the clinical presentation of this case.
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