Publisher: Bentham Science Publishers
E-ISSN: 1875-5828|15|4|381-385
ISSN: 1567-2050
Source: Current Alzheimer Research, Vol.15, Iss.4, 2018-02, pp. : 381-385
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Abstract
Objective: The aim of the study was to investigate if erythrocyte associated A#946; (iA#946;) levels could bedifferent in subjects affected by dementia in comparison with controls and according to the patient’scognitive impairment or different dementia subtypes. Method: To answer these questions we assessed iA#946;40 and iA#946;42 levels in 116 patients: 32 healthycontrols, 39 with diagnosis of vascular dementia (VaD), 14 mild cognitive impairment (MCI) and 31AD. Results: In this population we found significant differences in iA#946;42 between controls and cognitiveimpaired patients. Moreover, iA#946;42 significantly differed between dementia vs MCI. AD also showeddifferent iA#946;42 levels as compared to VaD. Conversely, no differences were found for iA#946;40. All theanalyses were adjusted for potential confounders like age, gender and Hb concentration. A direct correlationbetween increasing iA#946;42 concentration and the progression of the cognitive decline using theMMSE score as continuous variable was also found. Conclusion: Our findings support the evidence that iA#946;42 could be an instrument to early recognizedementia and predict cognitive impairment.
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