Phyto-glycosides as Therapeutic Target in the Treatment of Diabetes

E-ISSN： 1875-5607|18|3|208-215

ISSN： 1389-5575

Source： Mini Reviews in Medicinal Chemistry, Vol.18, Iss.3, 2018-01, pp. : 208-215

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Abstract

Diabetes is a chronic metabolic disorder characterized by increased level of glucose in theblood due to defects in insulin action, insulin secretion or both. The effective management of diabetesis extremely important, otherwise, chronic uncontrolled diabetes could lead to diabetes late complicationsnamely neuropathy, retinopathy, cardiomyopathy and nephropathy. The survey has shown thatdiabetes mellitus is one of the five leading causes of death all over the world. The therapeutic agents inclinical practice are facing the challenge of several unwanted effects, ineffectiveness in a large populationand patient compliance therefore, new effective therapies are most warrant. In this connection, thenatural product could be the best option as already accepted therapeutic modality since time immemorial.This review encounters various plant derived glycosides with antidiabetic effects; mediatedthrough different mechanism(s). It is concluded that focusing glycosides as antidiabetic therapy couldlead to the discovery of some new effective therapeutic agents.