Statins Therapy for Connective Tissue Diseases: New Therapeutic Opportunities

E-ISSN： 2212-3873|18|2|135-147

ISSN： 1871-5303

Source： Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders), Vol.18, Iss.2, 2018-02, pp. : 135-147

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Abstract

Background and Objective: Statins, 3-hydroxyl-3-methyl-glutharyl Coenzyme A reductaseinhibitors showed their therapeutic potential in the treatment of atherosclerosis-related diseases. Recently,the properties of statins, separate from their lipid lowering activity have attracted much attention.These properties that cover a wide area of physiopathological activities including cell maturation,immune response regulation, tissue fibrosis, endothelial activity and are called pleiotropic activity.Many in vitro studies demonstrated significant, statins-dependent regulation of immune system reactivity,reduction of pro-inflammatory and pro-fibrotic cytokines as well as suppression of endothelialactivity and damage.lt;/Pgt