¹¹C-mHED for PET / CT: Principles of Synthesis, Methodology and First Clinical Applications

E-ISSN： 1874-4729|7|2|79-83

ISSN： 1874-4710

Source： Current Radiopharmaceuticals, Vol.7, Iss.2, 2014-12, pp. : 79-83

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Abstract

Alterations of the cardiac autonomic nervous system play an important role in the pathway of many heart diseases.Nuclear imaging tools have been demonstrated to be useful for global and regional assessment of myocardial innervation.We used lt;supgt;11lt;/supgt;C-meta-hydroxy-ephedrine (lt;supgt;11lt;/supgt;C-mHED), a catecholamine analogue, as a radiotracer usable with aPET/CT scanner to study the cardiac sympathetic system. After a fast and automatic synthesis of mHED and its labelingwith lt;supgt;11lt;/supgt;C, we acquired cardiac images by using a PET/ CT scanner. In this paper we present our preliminary results showingthe radiotracer bio-distribution in humans 10 minutes post injection. The present study assesses the feasibility ofPET/CT with the radiolabeled catecholamine analogue (lt;supgt;11lt;/supgt;C-mHED) in order to determine sympathetic innervation in thehuman heart.