Nanoparticulated Polymeric Systems for Gene Delivery

E-ISSN： 1873-4286|21|29|4193-4200

ISSN： 1381-6128

Source： Current Pharmaceutical Design, Vol.21, Iss.29, 2015-10, pp. : 4193-4200

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

Gene therapy, currently, represents one of the new therapies that have emerged for the treatment of differentdiseases. Between the different approaches that can be chosen concerning this therapy, gene delivery withnon-viral systems has focused the attention during the past decades, because of the reduced toxicity compared tothe viral systems. Non-viral vectors are formed by a group of different molecules with a wide variety of sourcesand features. Among them, polymeric systems have been extensively studied due to the ability to form nanoparticlesin the presence of nucleic acids, protect the included nucleic acid and more importantly, improve the entranceof the desired nucleic acid fragment into the cell and hopefully achieve a therapeutic effect. In this review, some ofthe most used polymeric systems are commented with the main characteristics that can influence the activity ofeach of them, such as the molecular weight, N/P ratio (positive charges of cationic polymer/negative charges ofpDNA), stability or the molecular structure.