MiR-106a Associated with Diabetic Peripheral Neuropathy Through the Regulation of 12/15-LOX-meidiated Oxidative/Nitrative Stress

Publisher： Bentham Science Publishers

E-ISSN： 1875-5739|14|2|117-124

ISSN： 1567-2026

Source： Current Neurovascular Research, Vol.14, Iss.2, 2017-06, pp. : 117-124

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Abstract

Background: Diabetic peripheral neuropathy (DPN) is a common complication ofdiabetes with a complex pathogenesis. Study has reported that oxidative stress and nitrativestress are all involved in the DPN. However, the mechanism between them is still unclear. In thepresent study, we investigated whether miR-106a regulated 12/15-Lipoxygenase (12/15-LOX) ofoxidative/nitrative stress (OS/NS) in DPN.lt;pgt

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