Relationship between CNS and Immunology: Correlation with Psychology

E-ISSN： 1875-5453|19|10|847-855

ISSN： 1389-2002

Source： Current Drug Metabolism, Vol.19, Iss.10, 2018-08, pp. : 847-855

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Abstract

Background: Higher animals, especially the human beings have the privilege of employing advancedcentral nervous system (CNS) as well as the evolved immune system to ward off various onslaughts throughout theirlife. Alterations in inflammatory and neural regulatory pathways lead to several disorders that are now becoming thecause of concern across the world. Deregulation in bidirectional network, particularly in aging population, leads toseveral neurodegenerative diseases such as dementia as a one of the major characteristics.

Objective: Interestingly, research updates have signified the role of abrupt immune regulation in several brain diseases,establishing a link between altered immune system and CNS related diseases. In the later period of life, thealtered immune response in the pathogenesis of major psychiatric disorders, has become more visible. In the presentmanuscript, we present a synopsis on the linkage of CNS and immune system with respect to psychology, with theaim to further understand the biological machinery of psychoneuroimmunological disorders. The immune system ofhuman being plays an important role in keeping pathogen onslaughts on bay.

Conclusion: Our manuscript concludes a close relationship between emotion and psychology to diseases and immunology,proclaiming the need of providing enhanced attention on mechanistic aspect of psychoneuroimmunologicaldisorders.