Unique Phenotypes and Functions of Follicular Helper T Cells and Regulatory T Cells in Sjögren’s Syndrome

E-ISSN： 1875-6360|14|3|239-245

ISSN： 1573-3971

Source： Current Rheumatology Reviews, Vol.14, Iss.3, 2018-11, pp. : 239-245

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Abstract

Sjogren’s syndrome (SS) is a T cell-mediated autoimmune disease of the systemic exocrineglands, such as salivary and lacrimal glands. A variety of T-cell subpopulations maintain immunetolerance in the thymus and periphery through complex immune responses including cellularand humoral immunity. The T-cell subpopulations exhibiting abnormal or unique phenotypes andimpaired functionality have been reported to play important roles in the cellular mechanisms ofautoimmunity in SS patients and animal models of SS. In this review, we focused on follicularhelper T cells related to antibody production and regulatory T cells to control immune tolerance inthe pathogenesis of SS. The unique roles of these T-cell subpopulations in the process of the onsetor development of SS have been demonstrated in this review of recent publications. The clinicalapplication of these T-cell subpopulations will be helpful for the development of new techniquesfor diagnosis or treatment of SS in the future.