Publisher: John Wiley & Sons Inc
E-ISSN: 1521-3757|127|49|15062-15065
ISSN: 0044-8249
Source: ANGEWANDTE CHEMIE, Vol.127, Iss.49, 2015-12, pp. : 15062-15065
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Abstract
AbstractA highly enantioselective gold(I)‐catalyzed intermolecular annulation of 2‐(1‐alkynyl)‐2‐alken‐1‐ones with N‐allenamides is presented. The present work represents the first example of a gold‐catalyzed annulation with the proximal CC bond of an N‐allenamide, and is distinctly different from the previously observed annulations at the distal CC bond. Interestingly, both enantiomers of the products could be obtained in good yields with high regio‐, diastereo‐, and enantioselectivity by using either diastereomer of a binol‐derived phosphoramidite as a chiral ligand.