Publisher： John Wiley & Sons Inc
E-ISSN： 1613-6829|11|44|5949-5955
ISSN： 1613-6810
Source： SMALL, Vol.11, Iss.44, 2015-11, pp. : 5949-5955
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Abstract
A new type of monodispersed mesoporous silica nanoparticles with a core–cone structure (MSN‐CC) has been synthesized. The large cone‐shaped pores are formed by silica lamellae closely packed encircling a spherical core, showing a structure similar to the flower dahlia. MSN‐CC has a large pore size of 45 nm and a high pore volume of 2.59 cm3 g−1. MSN‐CC demonstrates a high loading capacity of large proteins and successfully delivers active β‐galactosidase into cells, showing their potential as efficient nanocarriers for the cellular delivery of proteins with large molecular weights.
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