Publisher： Cambridge University Press
E-ISSN： 1469-8994|29|3|203-225
ISSN： 0033-5835
Source： Quarterly Reviews of Biophysics, Vol.29, Iss.3, 1996-08, pp. : 203-225
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Abstract
DNA supercoiling is a consequence of the double-stranded nature of DNA. When a linear DNA molecule is ligated into a covalently closed circle, the two strands become intertwined like the links of a chain, and will remain so unless one of the strands is broken. The number of times one strand is linked with the other is described by a fundamental property of DNA supercoiling, the linking number (Lk).
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